PENGARUH EKSTRAK BIJI SAGA DALAM MENGHAMBAT PERKEMBANGAN EMBRIO DAN KETEBALAN DINDING UTERUS TIKUS

Abstract

Abstract: The research was conducted to asses the effect of saga seed extract (Abrus precatorius L.) in thickness of uterus and development of blastocys. Female rat were divided into five treatment group: A1 (dosage I= 0,035 µg/g), A2 (dosage II=0,007 µg/g), A3 (dosage  III=0,14 µg/g). A4 (placebo/ natrium), dan A5 (control). Female rats were given saga seeds extract intraperitonially from gestation day 0.5 to 8.5. Uterine were removed on 4,5^th  and 8,5^th  day of  gestation . Observation uterine histological structure after preparation using paraffin method and hematoxylin-eosin staining. The result show the thickness of endometrium wall was decreased on treatment with dosage II, III, cause delayed development of embryo.

Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak biji saga (Abrus precatorius L.) terhadap ketebalan uterus tikus dan perkembangan blastosit. Tikus betina dibagi menjadi lima grup perlakuan A1 (dosis I=  0,035 µg/g), A2 (dosis II=0,007 µg/g), A3 (dosis  III=0,14 µg/g). A4 (plasebo/ natrium), dan A5 (kontrol). Tikus betina diberi ekstrak biji saga secara intraperitonial dari hari kehamilan 4,5 dan 8,5. Uterus diamati di hari kehamilan 4,5 dan 8,5. Pengamatan struktur histologis uterus menggunakan paraffin dan pewarnaan hematoksilin-eosin. Hasil menunjukkan ketebalan endometrium uterus menurun pada perlakuan dengan dosis III menyebabkan keterlambatan perkembangan embrio.